pentobarbital will decrease the level or outcome of ethotoin by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.
pentobarbital will lower the level or effect of armodafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
pentobarbital will decrease the level or result of fosaprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Cessation of benzodiazepines or other CNS depressants is chosen in most cases. In some cases, monitoring at a higher amount of look after tapering CNS depressants could be ideal. In Other folks, step by step tapering a affected individual off of a prescribed benzodiazepine or other CNS depressant or lowering to the lowest helpful dose can be correct.
Continuously monitor crucial signals in the course of sedation and recovery period if coadministered. Diligently titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
pentobarbital will lessen the level or effect of quetiapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lessen the extent or influence of sufentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
lasmiditan, pentobarbital. Either increases effects of the other by sedation. Use Warning/Watch. Coadministration of lasmiditan as well as other CNS depressant drugs, such as alcohol have not been evaluated in clinical research. Lasmiditan may induce sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
pentobarbital will lower the extent or influence of eltrombopag by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the level or result of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use more info Caution/Keep an eye on. Robust or moderate CYP3A4 inducers may well enhance rate of diazepam elimination; hence, efficacy of diazepam may very well be lowered.
Keep track of Intently (1)pentobarbital will lessen the level or impact of hydrocodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Warning when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone could boost and can lead to perhaps fatal respiratory depressionSerious - Use Choice (one)hydrocodone, pentobarbital.
pentobarbital will lessen the extent or influence of paclitaxel protein bound by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
pentobarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of CYP3A4 inducers may lower sufentanil concentrations and efficacy, perhaps precipitating withdrawal syndrome in people who may have developed physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers may perhaps improve sufentanil plasma concentration.
pentobarbital will reduce the extent or outcome of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.